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Proper ventilation plays a crucial role in building design, impacting several key factors that contribute to the overall health and comfort of indoor environments. While options A, B, and D highlight essential functions of ventilation, reducing insect infestations is not typically considered a primary benefit offered by proper ventilation systems.

Ventilation assists in the regulation of temperature by allowing for the exchange of indoor and outdoor air, thus helping to maintain a comfortable environment. It also contributes to maintaining air quality by removing pollutants, odors, and excess moisture, ensuring that the air inside a building remains healthy and safe for occupants. Additionally, effective ventilation helps to prevent moisture-related issues, such as mold growth and structural damage, by controlling humidity levels.

In contrast, while certain aspects of a building's design and maintenance can deter insects, proper ventilation does not specifically target insect infestations as its main function. Rather, it is more about ensuring that the living conditions within the building are optimal for human occupancy, which does not inherently include pest control.